ARTN Antibody
Product Specifications
Background
This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma.
NCBI Gene ID
9048
Swiss Prot
Q5T4W7
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human ARTN
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Growth Factors, Neuroscience
Purification
Affinity purification
Positive Control
22Rv1
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 28kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
ARTN
NCBI Official Name
Artemin
NCBI Organism
Homo sapiens
Other Product Names
EVN, NBN, ENOVIN, EVN, Artemin, Enovin
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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