PCSK9 Antibody

Product Specifications

Background

This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network. It is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

255738

Swiss Prot

Q8NBP7

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 600 to the C-terminus of human PCSK9 (NP_777596.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction, Stem Cell

Purification

Affinity purification

Positive Control

SW480

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 60kDa/72kDa

Fragment

IgG

Symbol

PCSK9

NCBI Official Name

Proprotein convertase subtilisin/kexin type 9

NCBI Organism

Homo sapiens

Other Product Names

Neural apoptosis regulated convertase 1, hypercholesterolemia, autosomal dominant 3, NARC1, NARC-1, HCHOLA3, FH3, proprotein convertase subtilisin/kexin type 9, PCSK9, PSEC0052