RBFOX1 Antibody
Product Specifications
Background
The Fox-1 family of RNA-binding proteins is evolutionarily conserved, and regulates tissue-specific alternative splicing in metazoa. Fox-1 recognizes a (U) GCAUG stretch in regulated exons or in flanking introns. The protein binds to the C-terminus of ataxin-2 and may contribute to the restricted pathology of spinocerebellar ataxia type 2 (SCA2) . Ataxin-2 is the product of the SCA2 gene which causes familial neurodegenerative diseases. Fox-1 and ataxin-2 are both localized in the trans-Golgi network. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
54715
Swiss Prot
Q9NWB1
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RBFOX1 (NP_665900.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Neuroscience
Purification
Affinity purification
Positive Control
SKOV3
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 43kDa
Fragment
IgG
Symbol
RBFOX1
Positive Control 2
Mouse brain
Positive Control 3
Mouse heart
Positive Control 4
Mouse skeletal muscle
Positive Control 5
Rat brain
Positive Control 6
Rat heart
NCBI Official Name
RNA binding protein, fox-1 homolog (C. elegans) 1
NCBI Organism
Homo sapiens
Other Product Names
A2BP1, 2BP1, FOX1, A2BP1, FOX-1, HRNBP1
Tested Applications
WB, IHC
Physical Properties
Liquid
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