HARS2 Antibody

Product Specifications

Background

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is an enzyme belonging to the class II family of aminoacyl-tRNA synthetases. Functioning in the synthesis of histidyl-transfer RNA, the enzyme plays an accessory role in the regulation of protein biosynthesis. The gene is located in a head-to-head orientation with HARS on chromosome five, where the homologous genes likely share a bidirectional promoter. Mutations in this gene are associated with the pathogenesis of Perrault syndrome, which involves ovarian dysgenesis and sensorineural hearing loss. Alternative splicing results in multiple transcript variants of this gene.

NCBI Gene ID

23438

Swiss Prot

P49590

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 217-506 of human HARS2 (NP_036340.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Affinity purification

Positive Control

U-251MG

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 50kDa

Fragment

IgG

Symbol

HARS2

Positive Control 2

Rat liver

NCBI Official Name

Histidyl-tRNA synthetase 2, mitochondrial

NCBI Organism

Homo sapiens

Other Product Names

HARSL, HARSR, HO3, HisRS, PRLTS2, probable histidine--tRNA ligase, mitochondrial, HARS-related, histidine tRNA ligase 2, mitochondrial (putative), histidine translase, histidine-tRNA ligase homolog, histidyl-tRNA synthetase 2, mitochondrial (putative), histidyl-tRNA synthetase 2, mitochondrial, hisRS, probable histidyl-tRNA synthetase, mitochondrial