DPM1 Antibody
Product Specifications
Background
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER) . Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
8813
Swiss Prot
O60762
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DPM1 (NP_003850.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
NCI-H460
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 30kDa
Fragment
IgG
Symbol
DPM1
Positive Control 2
HeLa
Positive Control 3
SKOV3
Positive Control 4
Mouse pancreas
Positive Control 5
Mouse liver
Positive Control 6
Mouse kidney
NCBI Official Name
Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
NCBI Organism
Homo sapiens
Other Product Names
DPM1, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, CDGIE, MPDS, dolichol monophosphate mannose synthase
Tested Applications
WB, IF
Physical Properties
Liquid
Frequently Asked Questions
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