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DPM1 Antibody

Product Specifications

Background

Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER) . Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

8813

Swiss Prot

O60762

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human DPM1 (NP_003850.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Affinity purification

Positive Control

NCI-H460

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=23-161

Calculated Molecular Weight

Observed: 30kDa

Fragment

IgG

Symbol

DPM1

Positive Control 2

HeLa

Positive Control 3

SKOV3

Positive Control 4

Mouse pancreas

Positive Control 5

Mouse liver

Positive Control 6

Mouse kidney

NCBI Official Name

Dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit

NCBI Organism

Homo sapiens

Other Product Names

DPM1, dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit, CDGIE, MPDS, dolichol monophosphate mannose synthase

Tested Applications

WB, IF

Physical Properties

Liquid

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