SHC1 Antibody
Product Specifications
Background
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
6464
Swiss Prot
P29353
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human SHC1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology, Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 46kDa, 52kDa, 66kDa
Fragment
IgG
Symbol
SHC1
Positive Control 2
U-251MG
Positive Control 3
MCF7
Positive Control 4
Mouse liver
Positive Control 5
Mouse heart
Positive Control 6
Mouse brain
NCBI Official Name
SHC (Src homology 2 domain containing) transforming protein 1
NCBI Organism
Homo sapiens
Other Product Names
SHC1, FLJ26504, SHC, SHCA, p52SHC, p66, p66SHC
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
