SETDB2 Antibody

Product Specifications

Background

This gene encodes a member of a family of proteins that contain a methyl-CpG-binding domain (MBD) and a SET domain and function as histone methyltransferases. This protein is recruited to heterochromatin and plays a role in the regulation of chromosome segregation. This region is commonly deleted in chronic lymphocytic leukemia. Naturally-occuring readthrough transcription occurs from this gene to the downstream PHF11 (PHD finger protein 11) gene. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

83852

Swiss Prot

Q96T68

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SETDB2 (NP_001153780.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Affinity purification

Positive Control

HL-60

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 82kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

SETDB2

Positive Control 2

Mouse thymus

Positive Control 3

Rat heart

NCBI Official Name

SET domain, bifurcated 2

NCBI Organism

Homo sapiens

Other Product Names

Histone-lysine N-methyltransfera, chronic lymphocytic leukemia deletion region gene 8 protein, OTTHUMP00000018418, KMT1F, DKFZp761J1217, DKFZp586I0123, CLLL8, CLLD8, C13orf4, SET domain, bifurcated 2, SETDB2