PRKAA2 Antibody
Product Specifications
Background
The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.
NCBI Gene ID
5563
Swiss Prot
P54646
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 343-552 of human PRKAA2 (NP_006243.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Autophagy, Cancer, Cell Cycle, Signal Transduction
Purification
Affinity purification
Positive Control
SW620
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=22-874
Calculated Molecular Weight
Observed: 69kDa
Fragment
IgG
Symbol
PRKAA2
Positive Control 2
NCI-H460
Positive Control 3
Mouse brain
Positive Control 4
Mouse heart
Positive Control 5
Rat skeletal muscle
NCBI Official Name
Protein kinase, AMP-activated, alpha 2 catalytic subunit
NCBI Organism
Homo sapiens
Other Product Names
PRKAA2, protein kinase, AMP-activated, alpha 2 catalytic subunit, PRKAA, AMPK-alpha-2 chain, AMPK2, AMPK, AMP-activated protein kinase alpha 2 catalytic subunit, 5'-AMP-activated protein kinase, catalytic alpha-2 chain
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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