PRKAA2 Antibody

Product Specifications

Background

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK) . AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

NCBI Gene ID

5563

Swiss Prot

P54646

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 343-552 of human PRKAA2 (NP_006243.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Autophagy, Cancer, Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

SW620

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 69kDa

Fragment

IgG

Symbol

PRKAA2

Positive Control 2

NCI-H460

Positive Control 3

Mouse brain

Positive Control 4

Mouse heart

Positive Control 5

Rat skeletal muscle

NCBI Official Name

Protein kinase, AMP-activated, alpha 2 catalytic subunit

NCBI Organism

Homo sapiens

Other Product Names

PRKAA2, protein kinase, AMP-activated, alpha 2 catalytic subunit, PRKAA, AMPK-alpha-2 chain, AMPK2, AMPK, AMP-activated protein kinase alpha 2 catalytic subunit, 5'-AMP-activated protein kinase, catalytic alpha-2 chain