ELAC2 Antibody

Product Specifications

Background

The protein encoded by this gene has a C-terminal domain with tRNA 3' processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

60528

Swiss Prot

Q9BQ52

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ELAC2 (NP_776065.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle

Purification

Affinity purification

Positive Control

MCF7

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 105kDa

Fragment

IgG

Symbol

ELAC2

Positive Control 2

NCI-H460

NCBI Official Name

ElaC ribonuclease Z 2

NCBI Organism

Homo sapiens

Other Product Names

ELAC2, ElaC (E. coli) homolog 2, ElaC homolog 2 (E. coli), ELC2, ElaC homolog protein 2, HPC2, RNase Z 2, Ribonuclease Z 2, TRNA 3 endonuclease 2, TRNase Z (long form), TRNase Z 2