UPF2 Antibody
Product Specifications
Background
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD) . When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.
NCBI Gene ID
26019
Swiss Prot
Q9HAU5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1153-1272 of human UPF2 (NP_542166.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
HT-29
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=22-689
Calculated Molecular Weight
Observed: 148kDa
Fragment
IgG
Symbol
UPF2
Positive Control 2
Jurkat
Positive Control 3
HepG2
Positive Control 4
Mouse brain
NCBI Official Name
UPF2 regulator of nonsense transcripts homolog (yeast)
NCBI Organism
Homo sapiens
Other Product Names
UPF2, UPF2 regulator of nonsense transcripts homolog (yeast), HGNC:17854, DKFZP434D222, HUPF2, KIAA1408, RENT2, OTTHUMP00000045025, UPF2 regulator of nonsense transcripts homolog, regulator of nonsense transcripts 2, yeast Upf2p homolog
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
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