COPS6 Antibody

Product Specifications

Background

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein belongs to translation initiation factor 3 (eIF3) superfamily. It is involved in the regulation of cell cycle and likely to be a cellular cofactor for HIV-1 accessory gene product Vpr.

NCBI Gene ID

10980

Swiss Prot

Q7L5N1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 58-327 of human COPS6 (NP_006824.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle

Purification

Affinity purification

Positive Control

MCF7

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 36kDa

Fragment

IgG

Symbol

COPS6

Positive Control 2

Jurkat

Positive Control 3

Mouse heart

Positive Control 4

Mouse brain

Positive Control 5

Mouse liver

Positive Control 6

Rat liver

NCBI Official Name

COP9 signalosome subunit 6

NCBI Organism

Homo sapiens

Other Product Names

CSN6, MOV34-34KD, COP9 signalosome complex subunit 6, COP9 constitutive photomorphogenic homolog subunit 6, H_NH0506M12.12, JAB1-containing signalosome subunit 6, MOV34 homolog, 34 kD, SGN6, hVIP, vpr-interacting protein