PDHB Antibody
Product Specifications
Background
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) . The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene.
NCBI Gene ID
5162
Swiss Prot
P11177
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human PDHB (NP_000916.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
HL-60
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=22-573
Calculated Molecular Weight
Observed: 39kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
PDHB
Positive Control 2
HeLa
Positive Control 3
Jurkat
Positive Control 4
U-937
Positive Control 5
Mouse skeletal muscle
Positive Control 6
Rat heart
NCBI Official Name
Pyruvate dehydrogenase (lipoamide) beta
NCBI Organism
Homo sapiens
Other Product Names
PDHB, DKFZp564K0164, PHE1B, PDHBD, PDHE1-B
Tested Applications
WB
Physical Properties
Liquid
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