HLA-DMA Antibody
Product Specifications
Background
HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages) . The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail.
NCBI Gene ID
3108
Swiss Prot
P28067
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 27-233 of human HLA-DMA (NP_006111.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Immunology
Purification
Affinity purification
Positive Control
A-431
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 35kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
HLA-DMA
Positive Control 2
Jurkat
Positive Control 3
HeLa
Positive Control 4
Mouse lung
NCBI Official Name
Major histocompatibility complex, class II, DM alpha
NCBI Organism
Homo sapiens
Other Product Names
D6S222E, DMA, HLADM, RING6, HLA class II histocompatibility antigen, DM alpha chain, MHC class II antigen DMA, class II histocompatibility antigen, M alpha chain, really interesting new gene 6 protein
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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