ASIP Antibody
Product Specifications
Background
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
NCBI Gene ID
434
Swiss Prot
P42127
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 23-132 of human ASIP (NP_001663.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Growth Factors, Neuroscience, Signal Transduction
Purification
Affinity purification
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Fragment
IgG
Symbol
ASIP
NCBI Official Name
Agouti signaling protein
NCBI Organism
Homo sapiens
Other Product Names
AGSW, AGTI, AGTIL, ASP, SHEP9, agouti-signaling protein, agouti signaling protein, nonagouti homolog, agouti switch protein, nonagouti homolog
Tested Applications
IHC, IF
Physical Properties
Liquid
Curated Selection
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