POLD2 Antibody

Product Specifications

Background

This gene encodes the 50-kDa catalytic subunit of DNA polymerase delta. DNA polymerase delta possesses both polymerase and 3' to 5' exonuclease activity and plays a critical role in DNA replication and repair. The encoded protein is required for the stimulation of DNA polymerase delta activity by the processivity cofactor proliferating cell nuclear antigen (PCNA) . Expression of this gene may be a marker for ovarian carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5.

NCBI Gene ID

5425

Swiss Prot

P49005

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 120-360 of human POLD2 (NP_006221.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Other

Purification

Affinity purification

Positive Control

HeLa

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 51kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

POLD2

Positive Control 2

HL-60

Positive Control 3

HepG2

Positive Control 4

BT-474

Positive Control 5

NCI-H460

Positive Control 6

Mouse testis

NCBI Official Name

DNA polymerase delta 2, accessory subunit

NCBI Organism

Homo sapiens

Other Product Names

DNA polymerase delta subunit 2, DAN polymerase delta 2, accessory subunit, DNA polymerase delta subunit p5Pol delta B subunit (p50), polymerase (DNA directed), delta 2, accessory subunit, polymerase (DNA directed), delta 2, regulatory subunit 50kDa, polymerase (DNA) delta 2, accessory subunit