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PDE5A Antibody

Product Specifications

Background

This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms.

NCBI Gene ID

8654

Swiss Prot

O76074

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human PDE5A (NP_001074.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

HT-1080

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=22-501

Calculated Molecular Weight

Observed: 100kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

PDE5A

Positive Control 2

SKOV3

Positive Control 3

A-549

Positive Control 4

22Rv1

Positive Control 5

Mouse brain

Positive Control 6

Mouse skeletal muscle

NCBI Official Name

Phosphodiesterase 5A, cGMP-specific

NCBI Organism

Homo sapiens

Other Product Names

PDE5A, CN5A, PDE5, PDE5A1, CGB-PDE, phosphodiesterase 5A, cGMP-specific, cGMP-binding cGMP-specific 3', 5'-cyclic nucleotide phosphodiesterase

Tested Applications

WB

Physical Properties

Liquid

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