PPM1A Antibody
Product Specifications
Background
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
NCBI Gene ID
5494
Swiss Prot
P35813
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-382 of human PPM1A (NP_066283.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
MCF-7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 42kDa
Fragment
IgG
Symbol
PPM1A
Positive Control 2
HeLa
Positive Control 3
HepG2
Positive Control 4
SH-SY5Y
Positive Control 5
Mouse liver
Positive Control 6
Mouse skeletal muscle
NCBI Official Name
Protein phosphatase, Mg2+/Mn2+ dependent, 1A
NCBI Organism
Homo sapiens
Other Product Names
PPM1A, PP2Calpha, Protein phosphatase 1A, Protein phosphatase 2C alpha, Protein phosphatase IA, PP2CA, PPPM1A, PP2C-ALPHA
Tested Applications
WB, IF
Physical Properties
Liquid
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