CCM2 Antibody
Product Specifications
Background
This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.
NCBI Gene ID
83605
Swiss Prot
Q9BSQ5
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human CCM2 (NP_113631.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience, Signal Transduction
Purification
Affinity purification
Positive Control
MCF7
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=22-300
Calculated Molecular Weight
Observed: 55kDa
Fragment
IgG
Symbol
CCM2
NCBI Official Name
Cerebral cavernous malformation 2
NCBI Organism
Homo sapiens
Other Product Names
CCM2, cerebral cavernous malformation 2, C7orf22, MGC4067, MGC4607, MGC74868, PP10187 , PP10187
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
FAB76161JF525 0.1 mL
Rabbit Monoclonal Integrin alpha 2b beta 3 Antibody (2530A) [Janelia Fluor 525]
Ask
View Details 
MBS6310594-01 0.1 mL
INPP5B, CT (INPP5B, OCRL2, Type II inositol 1,4,5-trisphosphate 5-phosphatase, 75kD inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase) (MaxLight 650)
Ask
View Details MBS6310594-02 5x 0.1 mL
INPP5B, CT (INPP5B, OCRL2, Type II inositol 1,4,5-trisphosphate 5-phosphatase, 75kD inositol polyphosphate-5-phosphatase, Phosphoinositide 5-phosphatase) (MaxLight 650)
Ask
View Details