ALAS1 Antibody
Product Specifications
Background
This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms.
NCBI Gene ID
211
Swiss Prot
P13196
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ALAS1 (NP_954635.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Signal Transduction
Purification
Affinity purification
Positive Control
SW480
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 70kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
ALAS1
Positive Control 2
THP-1
Positive Control 3
SW620
Positive Control 4
HepG2
Positive Control 5
Mouse liver
NCBI Official Name
Aminolevulinate, delta-, synthase 1
NCBI Organism
Homo sapiens
Other Product Names
ALAS1, ALAS, ALAS3, ALASH, MIG4
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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