Duclauxin

Duclauxin decreases proliferation of tumor cells in vitro and increases the lifespan of mice innoculated with Ehrlich ascitic tumor cells. Duclauxin (10-30 μg/mL) inhibits mitochondrial respiration of P-388 tumor cells and nucleic acid synthesis in cell culture of Ehrlich cancer, the lymphadenomas NK/LI and L 5178, and sarcoma 37. Duclauxin also inhibits growth of wheat coleoptile.

Product Specifications

CAS Number

[1732-37-2]

Product Name Alternative

NSC 258308

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/duclauxin.html

Smiles

O=C1C2=C(O)C=C(C)C3=C2[C@]4([C@@]([C@]5(OC)[C@@]([C@H]4OC(C)=O)([H])C3=O)([H])C(C6=COC(C7=C(O)C=C(C)C5=C76)=O)=O)CO1

Molecular Formula

C29H22O11

Molecular Weight

546.48

References & Citations

[1]Fusková, et al. In vitro effect of duclauxin and derivatives of coumarin on nucleic acid and protein synthesis in Ehrlich’s Ascites Carcinoma cells (EAC) . Pharmazie 32 (5), 291-293 (1977) .