CISH Antibody

Product Specifications

Background

The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

1154

Swiss Prot

Q9NSE2

Host

Rabbit

Reactivity

Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-257 of human CISH (NP_659508.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Signal Transduction

Purification

Affinity purification

Positive Control

Mouse liver

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 37kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

CISH

NCBI Official Name

Cytokine inducible SH2 containing protein

NCBI Organism

Homo sapiens

Other Product Names

BACTS2, CIS, CIS-1, G18, SOCS, cytokine-inducible SH2-containing protein, cytokine-inducible inhibitor of signaling type 1B, suppressor of cytokine signaling