CX3CR1 Antibody (biotin)

Product Specifications

Background

CX3CR1 Antibody: CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, murine, and rat CX3CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein was recently identified as the receptor for a novel transmembrane molecule, fractalkine, and renamed CX3CR1. Recently, CX3CR1 was found to serve as a coreceptor for HIV-1 and HIV-2 envelope fusion and virus infection, which can be inhibited by fractokine. CX3CR1 mediates leukocyte migration and adhesion. CX3CR1 is expressed in a variety of human tissues and cell lines.

NCBI Gene ID

1524

Swiss Prot

P49238

Accession Number

NP_001328

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

2093

Clonality

Polyclonal

Conjugation

Biotin

Type

Primary Antibodies

Field of Research

Chemokines & Cytokines, Cancer, Infectious Disease

Purification

CX3CR1 Antibody is affinity chromatography purified via peptide column.

Positive Control

Cat. No. 1306 - Human Spleen Tissue Lysate

Concentration

1 mg/mL

Homology

Predicted species reactivity based on immunogen sequence: Bovine: (82%)

Buffer

CX3CR1 Antibody is supplied in PBS containing 0.02% sodium azide.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

CX3CR1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Fragment

IgG

Isoform

Human CX3CR1 has 3 isoforms, including isoform 1 (355aa, 40kD), isoform 2 (387aa, 44kD), isoform 3 (362aa, 41kD) . Mouse CX3CR1 has one isoform (354aa, 40kD) and rat CX3CR1 also has one isoform (354aa, 40kD) . 2093 can detect all isoforms of human, mouse and rat.

Symbol

CX3CR1

Positive Control 2

Cat. No. 10-501 - Human Heart Tissue Slide

Positive Control 3

Cat. No. 1466 - Rat Spleen Tissue Lysate

Positive Control 4

Cat. No. 1208 - THP-1 Cell Lysate

NCBI Official Name

Chemokine (C-X3-C motif) receptor 1

NCBI Organism

Homo sapiens

Background Reference 01

Raport et al. Gene 1995;163:295-9.

Background Reference 02

Combadiere et al. DNA Cell Biol 1995;14:673-80.

Background Reference 03

Combadiere et al. Biochem Biophys Res Commun 1998;253:728-32.

Background Reference 04

Harrison et al. Neurosci Lett 1994;169:85-9.

Other Product Names

CX3CR1 Antibody: V28, CCRL1, GPR13, CMKDR1, GPRV28, CMKBRL1, CX3C chemokine receptor 1, Beta chemokine receptor-like 1, C-X3-C CKR-1

Tested Applications

ELISA

Protein ID

4503171

Physical Properties

Liquid

Available Sizes

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