ACO1 Antibody
Product Specifications
Background
The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Alternative splicing results in multiple transcript variants
NCBI Gene ID
48
Swiss Prot
P21399
Host
Rabbit
Reactivity
Mouse, Rat
Immunogen
A synthetic peptide of human ACO1
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Signal Transduction
Purification
Affinity purification
Positive Control
Mouse liver
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 100kDa
Fragment
IgG
Symbol
ACO1
Positive Control 2
Mouse kidney
Positive Control 3
Mouse ovary
Positive Control 4
Rat kidney
NCBI Official Name
Aconitase 1, soluble
NCBI Organism
Homo sapiens
Other Product Names
ACO1, IRP1, ACONS, HEL60, IREB1, IREBP, IREBP1
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
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