FUS Antibody, KO Validated
Product Specifications
Background
This gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex. The hnRNP complex is involved in pre-mRNA splicing and the export of fully processed mRNA to the cytoplasm. This protein belongs to the FET family of RNA-binding proteins which have been implicated in cellular processes that include regulation of gene expression, maintenance of genomic integrity and mRNA/microRNA processing. Alternative splicing results in multiple transcript variants. Defects in this gene result in amyotrophic lateral sclerosis type 6.
NCBI Gene ID
2521
Swiss Prot
P35637
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 297-526 of human FUS (NP_004951.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Cancer, Signal Transduction, Transcription
Purification
Affinity purification
Positive Control
U-937
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 70kDa
Fragment
IgG
Symbol
FUS
Positive Control 2
Jurkat
NCBI Official Name
Fused in sarcoma
NCBI Organism
Homo sapiens
Other Product Names
FUS, FUS-CHOP, FUS1, TLS, ALS6, ETM4, POMP75, HNRNPP2
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
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