FADD Antibody
Product Specifications
Background
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development.
NCBI Gene ID
8772
Swiss Prot
Q13158
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-208 of human FADD (NP_003815.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology, Neuroscience, Inflammasomes
Purification
Affinity purification
Positive Control
293T
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=19-878
Calculated Molecular Weight
Observed: 26kDa
Fragment
IgG
Symbol
FADD
Positive Control 2
MCF7
Positive Control 3
HeLa
Positive Control 4
Mouse liver
Positive Control 5
Mouse kidney
Positive Control 6
Mouse heart
NCBI Official Name
Fas (TNFRSF6) -associated via death domain
NCBI Organism
Homo sapiens
Other Product Names
FADD, GIG3, MORT1
Tested Applications
WB, IHC, IP
Physical Properties
Liquid
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