COMP Antibody
Product Specifications
Background
The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) .
NCBI Gene ID
1311
Swiss Prot
P49747
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 20-160 of human COMP (NP_000086.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Signal Transduction, Stem Cell
Purification
Affinity purification
Positive Control
SW620
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=19-873
Calculated Molecular Weight
Observed: 110kDa
Fragment
IgG
Symbol
COMP
Positive Control 2
U-251MG
Positive Control 3
HepG2
Positive Control 4
MCF7
Positive Control 5
Mouse skeletal muscle
NCBI Official Name
Cartilage oligomeric matrix protein
NCBI Organism
Homo sapiens
Other Product Names
EDM1, EPD1, MED, PSACH, THBS5, TSP5, cartilage oligomeric matrix protein, cartilage oligomeric matrix protein (pseudoachondroplasia, epiphyseal dysplasia 1, multiple), pseudoachondroplasia (epiphyseal dysplasia 1, multiple), thrombospondin-5
Tested Applications
WB, IF
Physical Properties
Liquid
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