TDG Antibody
Product Specifications
Background
The protein encoded by this gene belongs to the TDG/mug DNA glycosylase family. Thymine-DNA glycosylase (TDG) removes thymine moieties from G/T mismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine. With lower activity, this enzyme also removes thymine from C/T and T/T mispairings. TDG can also remove uracil and 5-bromouracil from mispairings with guanine. This enzyme plays a central role in cellular defense against genetic mutation caused by the spontaneous deamination of 5-methylcytosine and cytosine. This gene may have a pseudogene in the p arm of chromosome 12.
NCBI Gene ID
6996
Swiss Prot
Q13569
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TDG (NP_003202.3) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
HT-29
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 46kDa/92kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
TDG
Positive Control 2
MCF7
Positive Control 3
HL-60
Positive Control 4
Mouse stomach
Positive Control 5
Rat eye
Positive Control 6
Rat stomach
NCBI Official Name
G/T mismatch-specific thymine DNA glycosylase
NCBI Organism
Homo sapiens
Other Product Names
G/T mismatch-specific thymine DNA glycosylase, Thymine-DNA glycosylase, hTDG, TDG
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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