MSH3 Antibody
Product Specifications
Background
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer.
NCBI Gene ID
4437
Swiss Prot
P20585
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 617-761 of human MSH3 (NP_004696.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
SW620
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 140kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
MSH3
Positive Control 2
HepG2
Positive Control 3
Jurkat
NCBI Official Name
MutS homolog 3
NCBI Organism
Homo sapiens
Other Product Names
DUP, FAP4, MRP1, DNA mismatch repair protein Msh3, divergent upstream protein, epididymis secretory sperm binding protein, hMSH3, mismatch repair protein 1
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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