ITGA2B Antibody
Product Specifications
Background
This gene encodes a member of the integrin alpha chain family of proteins. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate through disulfide linkages to form a subunit of the alpha-IIb/beta-3 integrin cell adhesion receptor. This receptor plays a crucial role in the blood coagulation system, by mediating platelet aggregation. Mutations in this gene are associated with platelet-type bleeding disorders, which are characterized by a failure of platelet aggregation, including Glanzmann thrombasthenia.
NCBI Gene ID
3674
Swiss Prot
P08514
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 693-993 of human ITGA2B (NP_000410.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology, Signal Transduction, Stem Cell
Purification
Affinity purification
Positive Control
Mouse liver
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 135kDa
Fragment
IgG
Symbol
ITGA2B
NCBI Official Name
Integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)
NCBI Organism
Homo sapiens
Other Product Names
GT, GTA, CD41, GP2B, HPA3, CD41B, GPIIb, BDPLT2, BDPLT16, PPP1R93, ITGA2B
Tested Applications
WB, IF
Physical Properties
Liquid
Curated Selection
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