NFkB p100 / p52 Antibody
Product Specifications
Background
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) . The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants.
NCBI Gene ID
4791
Swiss Prot
Q00653
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide of human NFkB p100 / p52
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cancer, Cell Cycle, Immunology, Signal Transduction, Transcription
Purification
Affinity purification
Positive Control
HT-29
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 33kDa
Fragment
IgG
Symbol
NFKB2
Positive Control 2
A-549
Positive Control 3
HeLa
NCBI Official Name
Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NCBI Organism
Homo sapiens
Other Product Names
NFKB2, p52, p105, H2TF1, LYT10, CVID10, LYT-10, NF-kB2
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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