PSMF1 Antibody
Product Specifications
Background
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.
NCBI Gene ID
9491
Swiss Prot
Q92530
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-271 of human PSMF1 (NP_006805.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
Affinity purification
Positive Control
SW480
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=19-728
Calculated Molecular Weight
Observed: 35kDa
Fragment
IgG
Symbol
PSMF1
Positive Control 2
A-549
Positive Control 3
Mouse liver
Positive Control 4
Mouse testis
NCBI Official Name
Proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
NCBI Organism
Homo sapiens
Other Product Names
PSMF1, proteasome (prosome, macropain) inhibitor subunit 1 (PI31), PI31, RP4-545L17.1, proteasome inhibitor hP131 subunit, proteasome inhibitor subunit 1
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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