DHCR24 Antibody

Product Specifications

Background

This gene encodes a flavin adenine dinucleotide (FAD) -dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

NCBI Gene ID

1718

Swiss Prot

Q15392

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 227-516 of human DHCR24 (NP_055577.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Cell Cycle, Neuroscience

Purification

Affinity purification

Positive Control

U-87MG

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 55kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

DHCR24

Positive Control 2

HT-29

Positive Control 3

PC-12

Positive Control 4

NCI-H460

NCBI Official Name

Delta (24) -sterol reductase

NCBI Organism

Homo sapiens

Other Product Names

Delta (24) -sterol reductase, 24-dehydrocholesterol reductase, 3-beta-hydroxysterol delta-24-reductase, Diminuto/dwarf1 homolog, Seladin-1, DHCR24, KIAA0018