ACTL6A Antibody

This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described.

ACTL6, ARPN-BETA, Arp4, BAF53A, INO80K, actin-like protein 6A, 53 kDa BRG1-associated factor A, BAF complex 53 kDa subunit, BAF53, BRG1-associated factor 53A, INO80 complex subunit K, actin-related protein 4, actin-related protein Baf53a, arpNbeta, hArpN beta