APPL1 Antibody

Product Specifications

Background

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus.

NCBI Gene ID

26060

Swiss Prot

Q9UKG1

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human APPL1 (NP_036228.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cell Cycle, Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

SKOV3

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 95kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

APPL1

Positive Control 2

SH-SY5Y

Positive Control 3

293T

Positive Control 4

HL-60

Positive Control 5

Mouse brain

Positive Control 6

Mouse lung

NCBI Official Name

Adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

NCBI Organism

Homo sapiens

Other Product Names

APPL1, APPL, adaptor protein containing pH domain, PTB domain and leucine zipper motif, PTB domain and leucine zipper motif 1, DIP13alpha, APPL1, signaling adaptor protein DIP13alpha, AKT2 interactor, adaptor protein, phosphotyrosine interaction, PH domai