STING / TMEM173 Antibody

Product Specifications

Background

This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants.

NCBI Gene ID

340061

Swiss Prot

Q86WV6

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 170-379 of human STING / TMEM173 (NP_938023.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cancer, Chemokines & Cytokines, Immunology, Innate Immunity, Signal Transduction

Purification

Affinity purification

Positive Control

SKOV3

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 39kDa

Fragment

IgG

Symbol

TMEM173

Positive Control 2

THP-1

Positive Control 3

Mouse spleen

Positive Control 4

Mouse thymus

NCBI Official Name

Transmembrane protein 173

NCBI Organism

Homo sapiens

Other Product Names

MPYS Antibody: ERIS, MITA, MPYS, NET23, STING, ERIS, Stimulator of interferon genes protein, Endoplasmic reticulum interferon stimulator, hSTING

Tested Applications

WB, IHC, IP

Physical Properties

Liquid

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