PZP Antibody
Product Specifications
Background
The protein encoded by this gene is highly expressed in late-pregnancy serum and is similar in structure to alpha-2-macroglobulin. The encoded protein, which acts as a homotetramer, inhibits the activity of all four classes of proteinases. This protein contains cleavage sites for several proteinases. Upon binding of a proteinase, the conformation of this protein changes to trap the proteinase, limiting its activity. This protein appears to be elevated in the sera of presymptomatic Alzheimer's disease patients.
NCBI Gene ID
5858
Swiss Prot
P20742
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 620-740 of human PZP (NP_002855.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle, Immunology, Innate Immunity, Neuroscience
Purification
Affinity purification
Positive Control
U-87MG
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 164kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
PZP
Positive Control 2
Mouse liver
Positive Control 3
Rat liver
NCBI Official Name
PZP alpha-2-macroglobulin like
NCBI Organism
Homo sapiens
Other Product Names
CPAMD6, pregnancy zone protein, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6, Pregnancy zone protein, pregnancy-zone protein
Tested Applications
WB
Physical Properties
Liquid
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