MSH6 Antibody
Product Specifications
Background
This gene encodes a member of the DNA mismatch repair MutS family. In E. coli, the MutS protein helps in the recognition of mismatched nucleotides prior to their repair. A highly conserved region of approximately 150 aa, called the Walker-A adenine nucleotide binding motif, exists in MutS homologs. The encoded protein heterodimerizes with MSH2 to form a mismatch recognition complex that functions as a bidirectional molecular switch that exchanges ADP and ATP as DNA mismatches are bound and dissociated. Mutations in this gene may be associated with hereditary nonpolyposis colon cancer, colorectal cancer, and endometrial cancer. Transcripts variants encoding different isoforms have been described.
NCBI Gene ID
2956
Swiss Prot
P52701
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant protein of human MSH6
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 200kDa
Fragment
IgG
Symbol
MSH6
Positive Control 2
A-549
Positive Control 3
MCF7
Positive Control 4
Mouse thymus
NCBI Official Name
MutS homolog 6
NCBI Organism
Homo sapiens
Other Product Names
GTBP, GTMBP, HNPCC5, HSAP, p16DNA mismatch repair protein Msh6, G/T mismatch-binding protein, mutS protein homolog 6, mutS-alpha 160 kDa subunit, sperm-associated protein
Tested Applications
WB, IF
Physical Properties
Liquid
Curated Selection
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