RAD50 Antibody
Product Specifications
Background
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
NCBI Gene ID
10111
Swiss Prot
Q92878
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human RAD50 (NP_005723.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cell Cycle
Purification
Affinity purification
Positive Control
A-549
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 170kDa
Fragment
IgG
Symbol
RAD50
Positive Control 2
MCF7
Positive Control 3
293T
Positive Control 4
HepG2
Positive Control 5
NIH/3T3
Positive Control 6
Mouse testis
NCBI Official Name
RAD50 homolog (S. cerevisiae)
NCBI Organism
Homo sapiens
Other Product Names
DNA repair protein RAD50, hRAD50, NBSLD, RAD502, hRad50
Tested Applications
WB, IF, IP
Physical Properties
Liquid
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