RAMP2 Antibody

Product Specifications

Background

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs) . RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.

NCBI Gene ID

10266

Swiss Prot

O60895

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human RAMP2 (NP_005845.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Growth Factors, Signal Transduction

Purification

Affinity purification

Positive Control

A-549

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 15kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

RAMP2

Positive Control 2

BxPC-3

Positive Control 3

MCF7

NCBI Official Name

Receptor activity modifying protein 2

NCBI Organism

Homo sapiens

Other Product Names

Receptor activity-modifying protein 2, CRLR activity-modifying protein 2, calcitonin receptor-like receptor activity modifying protein 2, receptor (G protein-coupled) activity modifying protein 2, receptor (calcitonin) activity modifying protein 2