NFASC Antibody

Product Specifications

Background

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

NCBI Gene ID

23114

Swiss Prot

O94856

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 830-1100 of human NFASC (NP_001005388.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Neuroscience

Purification

Affinity purification

Positive Control

SH-SY5Y

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 150kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

NFASC

Positive Control 2

HeLa

Positive Control 3

HL-60

Positive Control 4

Mouse brain

Positive Control 5

Mouse pancreas

Positive Control 6

Rat brain

NCBI Official Name

Neurofascin

NCBI Organism

Homo sapiens

Other Product Names

Neurofascin homolog, OTTHUMP00000065324, OTTHUMP00000065323, OTTHUMP00000065319, OTTHUMP00000065316, NRCAML, NF, KIAA0756, FLJ46866, DKFZp686P2250, neurofascin, NFASC