NFASC Antibody
Product Specifications
Background
This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.
NCBI Gene ID
23114
Swiss Prot
O94856
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 830-1100 of human NFASC (NP_001005388.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Neuroscience
Purification
Affinity purification
Positive Control
SH-SY5Y
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 150kDa
Fragment
IgG
Applications Notes
WB: 1:500 - 1:2000
Symbol
NFASC
Positive Control 2
HeLa
Positive Control 3
HL-60
Positive Control 4
Mouse brain
Positive Control 5
Mouse pancreas
Positive Control 6
Rat brain
NCBI Official Name
Neurofascin
NCBI Organism
Homo sapiens
Other Product Names
Neurofascin homolog, OTTHUMP00000065324, OTTHUMP00000065323, OTTHUMP00000065319, OTTHUMP00000065316, NRCAML, NF, KIAA0756, FLJ46866, DKFZp686P2250, neurofascin, NFASC
Tested Applications
WB
Physical Properties
Liquid
Curated Selection
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