GAD1 Antibody

Product Specifications

Background

This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.

NCBI Gene ID

2571

Swiss Prot

Q99259

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GAD1 (NP_000808.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Immunology, Neuroscience, Signal Transduction

Purification

Affinity purification

Positive Control

SKOV3

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 67kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

GAD1

Positive Control 2

Jurkat

Positive Control 3

Mouse pancreas

NCBI Official Name

Glutamate decarboxylase 1 (brain, 67kDa)

NCBI Organism

Homo sapiens

Other Product Names

GAD1, SCP, OTTHUMP00000204995, OTTHUMP00000204994, OTTHUMP00000204993, OTTHUMP00000204990, glutamate decarboxylase 67 kDa isoform, glutamate decarboxylase 1 (brain, 67kDa), glutamate decarboxylase 1, GAD-67, GAD, FLJ45882, 67 kDa glutamic acid decarboxylase, GAD67