EPOR Antibody
Product Specifications
Background
This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.
NCBI Gene ID
2057
Swiss Prot
P19235
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 274-508 of human EPOR (NP_000112.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Apoptosis, Cell Cycle, Immunology, Signal Transduction, Stem Cell
Purification
Affinity purification
Positive Control
K-562
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 55kDa
Fragment
IgG
Symbol
EPOR
Positive Control 2
Mouse kidney
Positive Control 3
Rat liver
NCBI Official Name
Erythropoietin receptor
NCBI Organism
Homo sapiens
Other Product Names
EPOR, MGC138358, EPO-R
Tested Applications
WB, IHC
Physical Properties
Liquid
Curated Selection
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