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APC Antibody

Product Specifications

Background

This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.

NCBI Gene ID

324

Swiss Prot

P25054

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 2544-2843 of human APC (NP_000029.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cancer, Cell Cycle, Neuroscience, Signal Transduction, Stem Cell, Transcription

Purification

Affinity purification

Positive Control

HeLa

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Product Datasheet

https://www.prosci-inc.com/?datasheet_sku=18-827

Calculated Molecular Weight

Observed: 290kDa

Fragment

IgG

Symbol

APC

NCBI Official Name

Adenomatous polyposis coli

NCBI Organism

Homo sapiens

Other Product Names

APC, Adenomatosis polyposis coli, Adenomatous polyposis coli, BTPS2, Deleted in polyposis 2.5, DP2, DP2.5, FPC, GS, Protein APC, PPP1R46, DP3

Tested Applications

WB, IHC, IF

Physical Properties

Liquid

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