APEX1 Antibody, KO Validated
Product Specifications
Background
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.
NCBI Gene ID
328
Swiss Prot
P27695
Host
Rabbit
Reactivity
Human
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-318 of human APEX1 (NP_542380.1) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Transcription
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 39kDa
Fragment
IgG
Symbol
APEX1
Positive Control 2
HepG2
NCBI Official Name
APEX nuclease (multifunctional DNA repair enzyme) 1
NCBI Organism
Homo sapiens
Other Product Names
APEX1, APE, APX, APE1, APEN, APEX, HAP1, REF1
Tested Applications
WB, IF, IP
Physical Properties
Liquid
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