TNXB Antibody

Product Specifications

Background

This gene encodes a member of the tenascin family of extracellular matrix glycoproteins. The tenascins have anti-adhesive effects, as opposed to fibronectin which is adhesive. This protein is thought to function in matrix maturation during wound healing, and its deficiency has been associated with the connective tissue disorder Ehlers-Danlos syndrome. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. It is one of four genes in this cluster which have been duplicated. The duplicated copy of this gene is incomplete and is a pseudogene which is transcribed but does not encode a protein. The structure of this gene is unusual in that it overlaps the CREBL1 and CYP21A2 genes at its 5' and 3' ends, respectively. Multiple transcript variants encoding different isoforms have been found for this gene.

NCBI Gene ID

7148

Swiss Prot

P22105

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 444-673 of human TNXB (NP_115859.2) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

Mouse liver

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 69kDa

Fragment

IgG

Applications Notes

WB: 1:500 - 1:2000

Symbol

TNXB

Positive Control 2

Mouse kidney

Positive Control 3

Rat liver

NCBI Official Name

Tenascin XB

NCBI Organism

Homo sapiens

Other Product Names

EDS3, EDSCLL, EDSCLL1, HXBL, TENX, TN-X, TNX1, TNXB2, TNXBS, VUR8, XB, XBS, TNXB, tenascin-X, growth-inhibiting protein 45, hexabrachion-like protein, tenascin XB1, tenascin XB2