AXC-715 (trihydrochloride)

AXC-715 (T785) trihydrochloride is a TLR7/TLR8 dual agonist. AXC-715 trihydrochloride can be used for synthesis of antibody-adjuvant immunoconjugates, comprising an antibody construct that binds programmed death-ligand 1 (PD-L1) linked to one or more adjuvants[2].

Product Specifications

CAS Number

[2479276-17-8]

Product Name Alternative

T785 (trihydrochloride)

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/axc-715-trihydrochloride.html

Concentration

10mM

Purity

99.76

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NC1=NC2=C(C=CC=C2)C3=C1N=C(CCCC)N3CCCCN.Cl.Cl.Cl

Molecular Formula

C18H28Cl3N5

Molecular Weight

420.81

Precautions

H302, H315, H319, H335

References & Citations

[1]Sung-Ju Moon, et al. Compositions containing, methods and uses of antibody-tlr agonist conjugates. Patent WO2020168017A1.|[2]Shelley Erin ACKERMAN, et al. Immunoconjugates targeting pd-l1. Patent WO2020190734A1.