OAS1 Antibody
Product Specifications
Background
This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As) . This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12.
NCBI Gene ID
4938
Swiss Prot
P00973
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-364 of human OAS1 (NP_002525.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Affinity purification
Positive Control
Mouse liver
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Calculated Molecular Weight
Observed: 40kDa
Fragment
IgG
Symbol
OAS1
NCBI Official Name
2'-5'-oligoadenylate synthetase 1, 40/46kDa
NCBI Organism
Homo sapiens
Other Product Names
OAS1, IFI-4, OIAS, OIASI
Tested Applications
WB, IF
Physical Properties
Liquid
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