TTK Antibody

Product Specifications

Background

This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.

NCBI Gene ID

7272

Swiss Prot

P33981

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 517-856 of human TTK (NP_001160163.1) .

Clonality

Polyclonal

Conjugation

Unconjugated

Type

Primary Antibodies

Field of Research

Apoptosis, Cell Cycle, Signal Transduction

Purification

Affinity purification

Positive Control

U-251MG

Concentration

Batch dependent

Buffer

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Modification

None

Shipping Conditions

Blue Ice

Storage Conditions

Store at -20˚ C. Avoid freeze / thaw cycles.

Calculated Molecular Weight

Observed: 97kDa

Fragment

IgG

Symbol

TTK

Positive Control 2

Mouse testis

Positive Control 3

Mouse spleen

NCBI Official Name

TTK protein kinase

NCBI Organism

Homo sapiens

Other Product Names

CT96, ESK, MPH1, MPS1, MPS1L1, PYT, dual specificity protein kinase TTK, cancer/testis antigen 96, monopolar spindle 1 kinase, monopolar spindle 1-like 1, phosphotyrosine picked threonine kinase, phosphotyrosine picked threonine-protein kinase