CBX3 Antibody, KO Validated
Product Specifications
Background
At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.
NCBI Gene ID
11335
Swiss Prot
Q13185
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-183 of human CBX3 (NP_009207.2) .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Validation
Antibody is Knockout validated.
Field of Research
Other
Purification
Affinity purification
Positive Control
HeLa
Concentration
Batch dependent
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at -20˚ C. Avoid freeze / thaw cycles.
Product Datasheet
https://www.prosci-inc.com/?datasheet_sku=18-588
Calculated Molecular Weight
Observed: 23kDa
Fragment
IgG
Symbol
CBX3
Positive Control 2
MCF-7
Positive Control 3
293T
Positive Control 4
A-549
Positive Control 5
NCI-H460
Positive Control 6
Mouse brain
NCBI Official Name
Chromobox homolog 3
NCBI Organism
Homo sapiens
Other Product Names
CBX3, HECH, HP1-GAMMA, HP1Hs-gamma
Tested Applications
WB, IHC, IF
Physical Properties
Liquid
Curated Selection
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